| Product Name: | SDHB Polyclonal Antibody |
| Cat No.: | D-AB-10362L |
| Clonality: | Polyclonal |
| Species Reactivity: | Human |
| Tested Applications: | IHC |
| Recommended Dilution: | IHC 1:75-1:150 |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Antigen Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Unconjugated |
| Storage: | Store at -20℃. Avoid freeze / thaw cycles. |
| Immunogen: | Recombinant Human SDHB protein expressed by E.coli |
| Gene ID (NCBI): | 6390 |
| Background: | Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. |
| Category: | Primary Ab |
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