Cat No.: D-AB-10188L

规格：

Product Name:	CD22 Polyclonal Antibody
Cat No.:	D-AB-10188L
Clonality:	Polyclonal
Species Reactivity:	Human
Tested Applications:	WB,IHC
Recommended Dilution:	WB 1:500-1:1000, IHC 1:200-1:400
Format:	Liquid
Source:	Rabbit
Purification Method:	Antigen Affinity Purification
Isotype:	IgG
Conjugate:	Unconjugated
Storage:	Store at -20℃. Avoid freeze / thaw cycles.
Immunogen:	Recombinant Human CD22 protein expressed by E.coli
Calculated Molecular Weight:	95kDa
Observed Molecular Weight:	135kDa
Background:	CD22,also known as Siglec-2 (sialic acid binding Ig-like lectin 2) or BL-CAM (B-lymphocyte cell adhesion molecule),is a 130-140 kDa,B-cell restricted,type I transmembrane glycoprotein belonging to the immunoglobulin gene superfamily. The expression of CD22 is developmentally regulated. It is expressed at low levels in the cytoplasm of pro-B and pre-B cells and present on the cell surface only at mature stages of B-cell differentiation. Cell surface expression is lost during terminal differentiation into plasma cell and after B-cell activation. CD22 is an inhibitory receptor for B-cell receptor (BCR) signalling,preferentially binds to alpha-2,6-linked sialic acid and mediates B-cell B-cell interactions. It plays a crucial role in activation and differentiation of the B-cell.
Category:	Primary Ab

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