| Product Name: | SNCA Polyclonal Antibody |
| Cat No.: | D-AB-10173L |
| Clonality: | Polyclonal |
| Species Reactivity: | Human,Mouse,Rat |
| Tested Applications: | WB |
| Recommended Dilution: | WB:1:500-1:1000 |
| Format: | Liquid |
| Source: | Rabbit |
| Purification Method: | Antigen Affinity Purification |
| Isotype: | IgG |
| Conjugate: | Unconjugated |
| Storage: | Store at -20℃. Avoid freeze/thaw cycles. |
| Immunogen: | Recombinant Human SNCA protein expressed by E.coli |
| Calculated Molecular Weight: | 14 kDa |
| Observed Molecular Weight: | 16 kDa |
| Background: | Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release.Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores.Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis.Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. |
| Category: | Primary Ab |
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